Biochemical Effects on the Liver and Kidney of Rats Administered Aqueous Leaf Extract of Guira Senegalensis

Abstract: Effect of crude aqueous extract of guira senegalensis on liver and kidney of albino rats have been investigated. The levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of treated animals have significantly increased compared to the control group. Increased levels of these enzymes appeared dose dependent. Both ALT and AST have significantly (p>0.005) increased in animals treated with the highest dose (900mg/kg) compared to the control and other treated groups. Similarly, serum levels of urea and creatinine of treated animals have significant (p<0.005) increase compared to the control group. The result is suggestive of liver and kidney impairment by the crude extract