SCREENING AND COMPARISON OF IN-VITRO ANTI HELMENTHIC ACTIVITYOF INDIVIDUAL CURCUMINOIDS WITH CHLOROFORM EXTRACT

Received on 02-01-2014 Accepted on 24-01-2014 The anthelmintic activity of chloroform extracts of rhizomes of curcuma longa Linn. Were evaluated separately on Indian adult earth worm’s pheretima posthuma (annelid) for this work the rhizomes were extracted separately with chloroform and distilled water following by percolation method. Various concentrations (10, 50,100,200mg/ml) of each extract were tested for anthelmentic activity which involved the determination of time of paralysis and time of death of the worms. The curcuma longa crude extract showing the presence of curcuminoids(curcumin, Demethoxy curcumin,Bisdemethoxy curcumin).All extract were able to show anthelmintic activity at all concentrations. The activities are well comparable with the standard drug, Albendazole as positive control. All the chloroform extracts showed better anthelmintic activity comparable with that of the standard drug. 10 % Propylene glycol in normal saline was used as negative control, did not showed any anthelmintic activity