Add to ORKG8 In biological systems, closure refers to a holistic fea-9 ture such that their constitutive processes, operations, 10 and transformations (1) depend on each other for their 11 production and maintenance and (2) collectively con-12 tribute to determine the conditions at which the whole 13 ▶ organization can exist. 14 According to several theoretical biologists, the con-15 cept of closure captures one of the central features of 16 biological organization since it constitutes, as well as 17 evolution by natural selection, an emergent and dis-18 tinctively biological causal regime. In spite of an 19 increasing agreement on its relevance to understand 20 biological systems, no agreement on a unique defini-21 tion has been reached so far. 22 Ch...