[Orthopedic Reviews 2009; 1:e32] [page 99] Safety of autologous bonemarrow aspiration concentratetransplantation: initial experiences in 101 patients

The clinical application of cellular based therapies with ex vivo cultivation for the treat-ment of diseases of the musculoskeletal sys-tem has until now been limited. In particular, the advanced laboratory and technical effort necessary, regulatory issues as well as high costs are major obstacles. On the other hand, newly developed cell therapy systems permit intra-operative enrichment and application of mesenchymal and progenitor stem cells from bone marrow aspirate concentrate (BMAC) in one single operative session. The objective of the present clinical surveillance study was to evaluate new bone formation after the applica