Establishment of Reference Ranges for Ferritin in Neonates, Infants, Children and Adolescents

Summary: Ferritin was determined in the sera of 631 healthy neonates, infants, children and adolescents (age range 5 days to 18 years), using the IMx from Abbott Laboratories. The applied test was a microparticle enzyme immunoassay (MEIA). The proband collective was divided into 9 age groups, and each group into males and females. In accordance with the recommendations of the International Federation of Clinical Chemistry, the 95 % scatter range was taken as the reference range. Only a few reference groups showed a normal Gaussian distribution. In addition to the 50th percentile, the 2.5th and 97.5th percentile were calculated for all reference groups, and the minimal and maximal values were also reported. Significantly different reference ranges were found for males and females in the age group 16 — 18 years. The U-test of Mann & Whitney was used to test for significant differences between individual reference groups. Groups showing no significant differences were combined, and the corresponding reference ranges for serum ferritin were then calculated