Primary Care Respiratory Journal (2010); 19(1): 57-61 ORIGINAL RESEARCH Recent trends in lung cancer and its association with COPD: an analysis using the UK GP Research Database

Background: The association between lung cancer and COPD has not been investigated in the primary care setting. Method: We determined the recent trends of lung cancer in COPD patients in the UK during the period 1991-2004, by investigating the population aged 45 and over in the General Practice Research Database. Results: The annual-incidence rates of lung cancer per 10,000 person-years were at least four-fold higher in patients with prior COPD (increasing from 45 to 64 in men; 29 to 48 in women) compared with the general population (from 10 to 15 in men; 5 to 10 in women). These lung cancer trends had significant annual increases that were similar in men (5%) and in women (5.5%) with prior COPD; in contrast, the annual increases of lung cancer incidence rates in the general population differed by gender, being 4 % in men but double in women (8%). The three-year survival for lung cancer patients among those with prior COPD was almost half that of the general population (15 % versus 26%; p<0.01) and the highest mortality was observed in men aged 45-64 (83.79 per 100 person-years; 95 % CI