Urinary glutathione-S-transferase in cisplatin nephrotoxicity in the rat

Summary: Rats given a single toxic dose of cisplatin all developed detectable glutathione-S-transferase activity in their urine between the third and fifth day after injection of cisplatin, simultaneously with the decreased urine osmplality and increased urine volume characteristic of cisplatin nephrotoxicity. Peak urinary glutathione-S-transferase levels occurred at the same time äs maximal serum creatinine levels, and there was a significant statisticäl correlation between these two variables. These findings suggest that urinary gluta-thione-S-transferase activity is a marker for proximal renal tubular injury from cisplatin. Nephrotoxizität von Cisplatin bei der Ratte: Ausscheidung von Glutathion-S-transferase im Harn Zusammenfassung: Ratten erhielten eine toxische Einzeldosis von Cisplatin. Alle Tiere entwickelten zwische