Add to ORKGA method is presented for achieving high entrapment efficiencies of a hydrophilic drug simulant, sulforhodamine B (SRB), in nanometer-scale liposomes using a continuous-flow microfluidic system. Liposome size and size dispersion are determined using tandem Asymmetric Flow Field Flow Fractionation (AF4) and Multi-Angle Laser Light Scattering (MALLS). The average number of encapsulated SRB molecules in a single liposome is measured with Fluorescence Correlation Spectroscopy (FCS) and Fluorescence Cumulant Analysis (FCA). Our results show that this system allows for controlled loading of SRB into the liposomes with high entrapment efficiencies (EE) measured as a ratio of SRB concentration inside the liposome to SRB starting concentration in th...
Microfluidics has recently emerged as a new method of manufacturing liposomes, which allows for repr...
In recent years, much research has focused on investigating new methods of drug delivery. One of the...
The low membrane permeability of candidate drug molecules is a major challenge in drug development, ...
Microfluidics is a powerful technology that allows the production of cationic liposomes by the hydro...
Liposomes are spherical vesicles made up of one or more lipid bilayers that can contain an aqueous m...
Injectable liposomes are characterized by a suitable size and unique lipid mixtures, which require t...
Injectable liposomes are characterized by a suitable size and unique lipid mixtures, which require t...
This paper presents the continuous flow formation by two-dimensional (2D) hydrodynamic flow focusing...
Liposomes are currently well-established as biocompatible delivery vehicles for numerous compounds. ...
Liposomes are currently well-established as biocompatible vehicles for the delivery of a range of bi...
Continuous‐flow production of liposomes using microfluidic reactors has demonstrated advantages comp...
Despite the substantial body of research investigating the use of liposomes, niosomes and other bila...
Liposome size and in vitro release of the active substance belong to critical quality attributes of ...
Liposomes used for the delivery of pharmaceuticals have difficulties scaling up and reaching clinica...
The production of reproducible batches of liposomes suitable for parenteral administration is a time...
Microfluidics has recently emerged as a new method of manufacturing liposomes, which allows for repr...
In recent years, much research has focused on investigating new methods of drug delivery. One of the...
The low membrane permeability of candidate drug molecules is a major challenge in drug development, ...
Microfluidics is a powerful technology that allows the production of cationic liposomes by the hydro...
Liposomes are spherical vesicles made up of one or more lipid bilayers that can contain an aqueous m...
Injectable liposomes are characterized by a suitable size and unique lipid mixtures, which require t...
Injectable liposomes are characterized by a suitable size and unique lipid mixtures, which require t...
This paper presents the continuous flow formation by two-dimensional (2D) hydrodynamic flow focusing...
Liposomes are currently well-established as biocompatible delivery vehicles for numerous compounds. ...
Liposomes are currently well-established as biocompatible vehicles for the delivery of a range of bi...
Continuous‐flow production of liposomes using microfluidic reactors has demonstrated advantages comp...
Despite the substantial body of research investigating the use of liposomes, niosomes and other bila...
Liposome size and in vitro release of the active substance belong to critical quality attributes of ...
Liposomes used for the delivery of pharmaceuticals have difficulties scaling up and reaching clinica...
The production of reproducible batches of liposomes suitable for parenteral administration is a time...
Microfluidics has recently emerged as a new method of manufacturing liposomes, which allows for repr...
In recent years, much research has focused on investigating new methods of drug delivery. One of the...
The low membrane permeability of candidate drug molecules is a major challenge in drug development, ...