Developmental Toxicity of a Commercial Herbicide Mixture in Mice: I. Effects on Embryo Implantation and Litter Size

Although they are not conclusive, a number of epidemiologic studies have linked pesticide exposure to reproductive and developmental toxicity in humans. Pastore et al. (1997) showed a clear positive association between occupational exposure to pesticides, especially during early pregnancy, and the risk of still-births in California, and Kristensen et al. (1997), associated central nervous system and limb defects with parental use of pesticide spraying equipment in Norway. In contrast, a case–control study in Holland determined lit-tle effect of pesticide exposure on the inci-dence of central nervous system defects in children of mothers involved in agricultura