Children’s Hospital Affiliated to Guangzhou Medical College,

AIM: To study the stability of portal hypertension (PHT) caused by partial ligation of the portal vein ligation (PVL) in a rat model. METHODS: Thirty male adult Wistar rats were divided into two groups: 10 in Group received a sham operation; and 20 in Group received partial PVL. Portal vein pressure (PVP) was measured at four time periods: before ligation, 2 wk, 6 wk and 10 wk post-surgery. Portal venography, blood sampling and liver and spleen pathological examinations were conducted at 10 wk after surgery. RESULTS: The PVP was 9.15 ± 0.58 cmH2O before ligation, and increased to 17.32 ± 0.63 cmH2O 2 wk after PVL. By repeat measurement of the PVP in each rat, i