The Management of Patients with Limited-Stage Classical Hodgkin Lymphoma

The term limited-stage Hodgkin lymphoma refers to those patients with stage I-II disease and an absence of bulky disease. Among those patients with classical Hodgkin lymphoma, approximately one-third of patients will fall into this category. As long-term disease control can now be anticipated in more than 90 % of these patients, management strategies must increasingly address the need to reduce the long-term treatment-related risks. Current treatment options include use of combined modality therapy that in-cludes an abbreviated course of chemotherapy and involved-field radiation or treatment with chemo-therapy, currently consisting of ABVD, as a single modality. The choice of treatment between these two options involves specific trade-offs that must balanc