We investigated about targeting for new antimalarial drugs using antisense (AS) oligodeoxynucleotides (ODNs). Synthetic nuclease-resistant ODNs (phosphorothioate (PS) ODNs and ODNs containing 4'a-C-(2-aminoethyI)thymidines (4'-amino ODNs)) which target mitochondrial succinate dehydrogenase (SDH) iron-sulfur subunit (IP), had antimalarial activity (EC^,; about 1.0 /iM). Furthermore we showed that intra-parasitic SDH IP mRNA levels, which were detected using quantitative RT-PCR assay, were decreased 13 % of control after the 24h expose to SDH IP AS. From the results, we conclude that SDH has potential as the target for novel antimalarials, and AS ODNs is effective for search and assessment of targets for new antunalarial drugs
Nowadays, several million people suffer from AIDS and more than 100 million people are forecasted to...
Malaria is one of the three major global health threats. Drug development for malaria, especially fo...
peer reviewedMalaria is a global health problem that causes significant mortality and morbidity, wit...
Antisense oligonucleotides and ribozymes have shown promise both as antimalarial agents and as tools...
The drive to propagate a species genes is among the strongest biological forces, shared by humans an...
The drive to propagate a species genes is among the strongest biological forces, shared by humans an...
Comparative biochemical studies between the malaria parasite, Plasmodium falciparum, and its host ha...
The Plasmodium falciparum lactate dehydrogenase enzyme (PfLDH) has been considered as a potential mo...
The Plasmodium falciparum lactate dehydrogenase enzyme (PfLDH) has been considered as a potential mo...
The efficacy of existing antimalarials is threatened by parasite resistance, driving the need for a ...
The efficacy of existing antimalarials is threatened by parasite resistance, driving the need for a ...
The growing resistance to current first-line antimalarial drugs represents a major health challenge....
Summary Preventing transmission is an important element of malaria control. However, most of the cur...
SummaryPreventing transmission is an important element of malaria control. However, most of the curr...
Malaria is a global health problem that causes significant mortality and morbidity, with more than 1...
Nowadays, several million people suffer from AIDS and more than 100 million people are forecasted to...
Malaria is one of the three major global health threats. Drug development for malaria, especially fo...
peer reviewedMalaria is a global health problem that causes significant mortality and morbidity, wit...
Antisense oligonucleotides and ribozymes have shown promise both as antimalarial agents and as tools...
The drive to propagate a species genes is among the strongest biological forces, shared by humans an...
The drive to propagate a species genes is among the strongest biological forces, shared by humans an...
Comparative biochemical studies between the malaria parasite, Plasmodium falciparum, and its host ha...
The Plasmodium falciparum lactate dehydrogenase enzyme (PfLDH) has been considered as a potential mo...
The Plasmodium falciparum lactate dehydrogenase enzyme (PfLDH) has been considered as a potential mo...
The efficacy of existing antimalarials is threatened by parasite resistance, driving the need for a ...
The efficacy of existing antimalarials is threatened by parasite resistance, driving the need for a ...
The growing resistance to current first-line antimalarial drugs represents a major health challenge....
Summary Preventing transmission is an important element of malaria control. However, most of the cur...
SummaryPreventing transmission is an important element of malaria control. However, most of the curr...
Malaria is a global health problem that causes significant mortality and morbidity, with more than 1...
Nowadays, several million people suffer from AIDS and more than 100 million people are forecasted to...
Malaria is one of the three major global health threats. Drug development for malaria, especially fo...
peer reviewedMalaria is a global health problem that causes significant mortality and morbidity, wit...