Editorial Does adiponectin resistance exist in chronic heart failure?

This editorial refers to ‘Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure ’ by T. Tsutamoto et al., on page 1723 Adiponectin is an adipocytokine, which is mainly expressed in adipose tissue and has been identified as a potent insulin-sensitzing hormone.1 Adiponectin administration lowers glucose levels and ameliorates insulin resistance in mice.1 In humans, plasma levels of adiponectin correlate inversely with visceral fat accumulation and insulin resistance.2 Pro-spective and longitudinal studies have demonstrated that lower adiponectin levels are closely associated with a higher incidence of type 2 diabetes mellitus.3 In addition, adiponectin exerts pronounced anti-atherogenic and anti-inflammatory actions; therefore, it is not surprising tha