Trial 6667 Investigators Group are listed

Even after careful clinical and mammographic evaluation, cancer is found in the contralateral breast in up to 10 % of women who have received treatment for unilat-eral breast cancer. We conducted a study to determine whether magnetic resonance imaging (MRI) could improve on clinical breast examination and mammography in detecting contralateral breast cancer soon after the initial diagnosis of unilateral breast cancer. Methods A total of 969 women with a recent diagnosis of unilateral breast cancer and no ab-normalities on mammographic and clinical examination of the contralateral breast underwent breast MRI. The diagnosis of MRI-detected cancer was confirmed by means of biopsy within 12 months after study entry. The absence of breast cance