Before 1950 the practice of medicine was basedlargely on observations of outcomes in one individ-ual or in small groups of patients. With the devel-opment of the randomized controlled trial (RCT) around the middle of the 20th century, medicine was rapidly transformed, as inferences increasingly were made on the basis of this experimental method.1 The first of these trials were conducted mainly to investigate infectious diseases. Because large effects were expected (e.g., a reduction in mortality rate or disease outcomes by greater than half), small trials were sufficient and could often be conducted by a single investigator. However, for most chronic dis-eases (e.g., cardiovascular disease or cancer) treatments are likely to have at best on...
In an era in which all aspects of medicine are being driven by evidence, one consequence has been an...
The placebo-controlled, double-blind, randomized clinical trial (RCT) holds unique advantages for ev...
Randomised controlled trials (RCTs) can be an invaluable tool in determining the best treatment for ...
nizing health research to better serve the health of Can-adians. I suggest that it will fail to do s...
When new drugs come to market and are pre-scribed by physicians to real-world patients,their costs a...
Comparisons are key to all fair tests of the effects of treatments. Sometimes patients experience re...
Randomized clinical trials (RCTs) are the definitive contributors to evidence-based medicine. RCTs a...
Clinical trials in the modern medical era began in themid-20th century with the first randomized, do...
In received biomedical research wisdom, randomized controlled trials (RCTs) revolutionized post-Worl...
Amajor factor in the rapid advance of medical scienceover the past 50 years has been the development...
Well-conducted randomized clinical trials (RCT) areessential for the objective assessment of the val...
Abstract: Randomized controlled trials (RCTs) constitute the gold standard for the generation of evi...
receding articles in this series have provided a great deal of in-formation concerning research desi...
Clinical cancer trials in the 21st century take place only with the ethics review committee’s approv...
SUMMARY Randomized clinical trials constitute the formal experiments in therapeutics. Many such tria...
In an era in which all aspects of medicine are being driven by evidence, one consequence has been an...
The placebo-controlled, double-blind, randomized clinical trial (RCT) holds unique advantages for ev...
Randomised controlled trials (RCTs) can be an invaluable tool in determining the best treatment for ...
nizing health research to better serve the health of Can-adians. I suggest that it will fail to do s...
When new drugs come to market and are pre-scribed by physicians to real-world patients,their costs a...
Comparisons are key to all fair tests of the effects of treatments. Sometimes patients experience re...
Randomized clinical trials (RCTs) are the definitive contributors to evidence-based medicine. RCTs a...
Clinical trials in the modern medical era began in themid-20th century with the first randomized, do...
In received biomedical research wisdom, randomized controlled trials (RCTs) revolutionized post-Worl...
Amajor factor in the rapid advance of medical scienceover the past 50 years has been the development...
Well-conducted randomized clinical trials (RCT) areessential for the objective assessment of the val...
Abstract: Randomized controlled trials (RCTs) constitute the gold standard for the generation of evi...
receding articles in this series have provided a great deal of in-formation concerning research desi...
Clinical cancer trials in the 21st century take place only with the ethics review committee’s approv...
SUMMARY Randomized clinical trials constitute the formal experiments in therapeutics. Many such tria...
In an era in which all aspects of medicine are being driven by evidence, one consequence has been an...
The placebo-controlled, double-blind, randomized clinical trial (RCT) holds unique advantages for ev...
Randomised controlled trials (RCTs) can be an invaluable tool in determining the best treatment for ...