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uMethods: A total of 653 patients were randomized to receive adapalene gel 0.3%, adapalene gel 0.1%, or vehicle once daily for 12 weeks (2:2:1 randomization). Analysis for efficacy was conducted on correlated repeated measurements at weeks 8 and 12 using Generalized Estimating Equation methodology. Results: Adapalene gel 0.3 % was significantly superior to adapalene gel 0.1 % and vehicle in success rate, total lesion count, and inflammatory lesion count. A consistent, dose-dependent effect was demonstrated for all efficacy measures. Signs and symptoms were mostly mild to moderate and transient in nature. Limitations: Adjunctive topical or oral agents and their impact on acne were not studied in this trial. Conclusions: Adapalene gel 0.3 % was effective and well tolerated in the treatment of acne. (J Am Acad Dermatol 2006;54:242-50.) A cne vulgaris is a chronic skin disease of the pilosebaceous unit, affecting approximately 80 % of young adults and adolescents.1-4 The management of acne can be challenging because of the variability in response to treatment and the need for long-term therapy. If not appropriately treated, acne may cause serious physical and emotional scar-ring and can significantly impact the quality of life of those affected by the disease.5,6 Currently, there is a variety of topical and systemic therapies that are recommended for the treatment of acne, includ-Abbreviations used