Reviews and Overviews Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex

processes underlying drug addiction pri-marily have focused on limbic subcortical structures. Here the authors evaluated the role of frontal cortical structures in drug addiction. Method: An integrated model of drug addiction that encompasses intoxication, bingeing, withdrawal, and craving is pro-posed. This model and findings from neu-roimaging studies on the behavioral, cog-nitive, and emotional processes that are at the core of drug addiction were used to analyze the involvement of frontal struc-tures in drug addiction. Results: The orbitofrontal cortex and th