Add to ORKGAIM: To examine the aberrant expression of fragile histidine triad (FHIT) gene and protein in gastric cancer, and to evaluate the role of FHIT gene and the relationship between FHIT gene and EBV infection in gastric carcinogenesis. METHODS: FHIT transcripts were detected by nested RT-PCR in 30 cases of gastric cancer and their products were sequenced. FHIT protein was detected by Western blot. EBV infection was detected by PCR method in 50 cases of gastric cancer. RESULTS: The wild type transcripts were detected in all 30 matched normal tissues of gastric cancer. Aberrant transcripts were found in 11/30 (36.7%) gastric cancerous tissues. Sequencing analysis of the aberrant fragments found an RT-PCR product missing exons 5-7 in one cas
Fhit protein is known to play a role in the process of neoplastic transformation. It has been demons...
arm of chromosome 3 are common in cervical carcinomas. The fragile histi-dine triad (FHIT) gene at c...
The FHIT gene, encoded by 10 exons in a 1.1-kb transcript, encompasses approximately 1 Mb of genomic...
Loss of heterozygosity involving the short arm of chromosome 3 has been reported in gastric and othe...
The fragile histidine triad (FHIT) gene is localized on chromosome 3p14 and spans the common fragile...
scription-polymerase chain reaction; nt, nucleotide(s) Aberrant transcripts of FHIT (fragile histidi...
To determine whether transcriptional alterations of the fragile histidine triad (FHIT) gene play a r...
The FHIT gene is a putative tumour suppressor gene. In this study, we analysed a set of 50 gastric t...
Chromosome 3p deletions in breast cancer have been detected at 3p12-p21 by cytogenetic and loss of h...
OBJECTIVE To investigate the relationship between fragile histidine triad (FHIT) depletion and human...
A link between common chromosome fragile sites and frequent chromosomal deletions in cancer was obse...
Cancer development follows an evolutionary pattern of “mutation-selection-adaptation” detailed by Ca...
The fragile histidine triad (FHIT) gene is a bonafide tumor-suppressor gene present on the short arm...
The FHIT gene is altered in several types of tumors and abnormal expression of Fhit protein have als...
Abstract Objectives In > 50% of cancers tumor development involves the early loss of Fhit (fragile h...
Fhit protein is known to play a role in the process of neoplastic transformation. It has been demons...
arm of chromosome 3 are common in cervical carcinomas. The fragile histi-dine triad (FHIT) gene at c...
The FHIT gene, encoded by 10 exons in a 1.1-kb transcript, encompasses approximately 1 Mb of genomic...
Loss of heterozygosity involving the short arm of chromosome 3 has been reported in gastric and othe...
The fragile histidine triad (FHIT) gene is localized on chromosome 3p14 and spans the common fragile...
scription-polymerase chain reaction; nt, nucleotide(s) Aberrant transcripts of FHIT (fragile histidi...
To determine whether transcriptional alterations of the fragile histidine triad (FHIT) gene play a r...
The FHIT gene is a putative tumour suppressor gene. In this study, we analysed a set of 50 gastric t...
Chromosome 3p deletions in breast cancer have been detected at 3p12-p21 by cytogenetic and loss of h...
OBJECTIVE To investigate the relationship between fragile histidine triad (FHIT) depletion and human...
A link between common chromosome fragile sites and frequent chromosomal deletions in cancer was obse...
Cancer development follows an evolutionary pattern of “mutation-selection-adaptation” detailed by Ca...
The fragile histidine triad (FHIT) gene is a bonafide tumor-suppressor gene present on the short arm...
The FHIT gene is altered in several types of tumors and abnormal expression of Fhit protein have als...
Abstract Objectives In > 50% of cancers tumor development involves the early loss of Fhit (fragile h...
Fhit protein is known to play a role in the process of neoplastic transformation. It has been demons...
arm of chromosome 3 are common in cervical carcinomas. The fragile histi-dine triad (FHIT) gene at c...
The FHIT gene, encoded by 10 exons in a 1.1-kb transcript, encompasses approximately 1 Mb of genomic...