Abstract: N-Acetyl-L-aspartate (NAA) and its derivative N-acetylaspartylglutamate (NAAG) are major osmolytes present in the vertebrate brain. Although they are synthe-sized primarily in neurons, their function in these cells is unclear. In the brain, these substances undergo inter-compartmental cycles in which they are released by neu-rons in a regulated fashion and are then rapidly hydro-lyzed by catabolic enzymes associated with glial cells. Recently, the catabolic enzyme for NAA hydrolysis has been found to be expressed only in oligodendrocytes, and the catabolic enzyme for NAAG expressed only in astrocytes. These results indicate an unusual tricellular metabolic sequence for the synthesis and hydrolysis of NAAG wherein it is synthesized...
The brain consists of a complex network in which neurones and glial cells are structurally and funct...
Although glial cells have been traditionally viewed as supportive partners of neurons, studies of th...
Canavan disease (CD) is an incurable, progressive leukodystrophy that develops in infancy as the res...
The dipeptide N-acetylaspartyl-glutamate (NAAG) is an abundant neuropeptide in the mammalian brain. ...
The brain is unique among organs in many respects, including its mechanisms of lipid synthesis and e...
N-acetylaspartate (NAA) is one of the most abundant molecules in the mammalian central nervous syste...
Oligodendroglial cells are known to de-acetylate the N-acetylaspartate (NAA) synthesized and release...
N-Acetylaspartate (NAA) is the second most abundant organic metabolite in the brain, but its physiol...
The brain-specific compound N-acetylaspartate (NAA) occurs almost exclusively in neurons, where its ...
N-acetylaspartate (NAA) is an amino acid derivative present in high concentration in the brain. The ...
The peptide N-acetylaspartylglutamate (NAAG) is present in high concentrations in the mammalian cent...
N-acetyl-aspartyl-glutamate (NAAG) is the most abundant dipeptide in the brain, where it acts as a n...
The glutamate-glutamine cycle faces a drain of glutamate by oxidation, which is balanced by the anap...
Studies of the last two decades have demonstrated the presence in astrocytic cell membranes of N-met...
Astrocytes are poly-functional cells that are present in all vertebrate central nervous systems. The...
The brain consists of a complex network in which neurones and glial cells are structurally and funct...
Although glial cells have been traditionally viewed as supportive partners of neurons, studies of th...
Canavan disease (CD) is an incurable, progressive leukodystrophy that develops in infancy as the res...
The dipeptide N-acetylaspartyl-glutamate (NAAG) is an abundant neuropeptide in the mammalian brain. ...
The brain is unique among organs in many respects, including its mechanisms of lipid synthesis and e...
N-acetylaspartate (NAA) is one of the most abundant molecules in the mammalian central nervous syste...
Oligodendroglial cells are known to de-acetylate the N-acetylaspartate (NAA) synthesized and release...
N-Acetylaspartate (NAA) is the second most abundant organic metabolite in the brain, but its physiol...
The brain-specific compound N-acetylaspartate (NAA) occurs almost exclusively in neurons, where its ...
N-acetylaspartate (NAA) is an amino acid derivative present in high concentration in the brain. The ...
The peptide N-acetylaspartylglutamate (NAAG) is present in high concentrations in the mammalian cent...
N-acetyl-aspartyl-glutamate (NAAG) is the most abundant dipeptide in the brain, where it acts as a n...
The glutamate-glutamine cycle faces a drain of glutamate by oxidation, which is balanced by the anap...
Studies of the last two decades have demonstrated the presence in astrocytic cell membranes of N-met...
Astrocytes are poly-functional cells that are present in all vertebrate central nervous systems. The...
The brain consists of a complex network in which neurones and glial cells are structurally and funct...
Although glial cells have been traditionally viewed as supportive partners of neurons, studies of th...
Canavan disease (CD) is an incurable, progressive leukodystrophy that develops in infancy as the res...