Ocular inserts for the controlled delivery of pefloxacin mesylate: preparation and evaluation. Acta pharm

Continuous delivery of drugs to the eye offers major advantages over conventional therapies that involve administration of drug solutions or suspensions as eye drops. Eye drop administration often results in poor bioavailability and therapeutic response due to rapid precorneal elimination of the drug and is also associated with patient compliance problems (1, 2). For this reason, several approaches have been reported and various oph