On localizing schizophrenic neuropathology

Many brain regions and circuits have been implicated in the neuropathology of schizophrenia. Drs. Bogerts and Jones have reviewed the evidence that links the disorder to temporal limbic structures and to frontal-thalamic circuits, respectively. Each article is an important update on what we know about the rele-vance of these brain regions to schizophrenia. In addi-tion, each article, in summarizing the accumulation of relevant research data, is a testament to the likelihood that these structures play a role in the disease. In light of their compelling arguments, this commentary emphasizes incompleteness in the data and inconsis-tencies in published findings. The principal weaknesses of the temporal limbic findings are that most hav