Evaluation of Serosal Nerves in Hirschsprung Disease

Introduction: For the diagnosis of Hirschsprung disease (HD) and related disorders the surgical pathologists evaluate the presence or absence of ganglion cells, the morphology of ganglion cells when present and the hypertrophy and hyperplasia of nerves in Auerbach’s and Meissener’s plexus.. The current economic health management issues make the attainment of a rapid reliable diagnosis of Hirschsprung disease highly desirable. An additional criterion apparent on hematoxylin & eosin stained sections would be of great diagnostic utility. The presence of submucosal hypertrophic or prominent nerve trunks i