Add to ORKGAIM: To explore the effect of DNA methyltransferase, demethylase and methyl-CpG binding protein MeCP2 on the expressions and methylation of hMSH2 and proto-oncogene in human gastric cancer. METHODS: Paired samples of primary gastric cancer and corresponding para-cancerous, non-cancerous gastric mucosae were obtained from surgically resected specimens of 28 patients. Transcription levels of Dnmt1, mbd2, MeCP2, p16INK4A, hMSH2 and c-myc were detected by using real-time PCR or RT-PCR. Promoter methylation of p16INK4A, c-myc and hMSH2 genes was assayed by methylation-specific PCR (MSP) and sequencing (mapping). Their relationships were analyzed by Fisher’s exact test using the software SPSS. RESULTS: The average mRNA level of Dnmt1 gene fro
Promoter hypermethylation is an alternative mechanism of gene silencing in human cancers including g...
DNA methylation has an important impact on normal cell physiology, thus any defects in this mechanis...
Background and Objective. Many factors are involved in the development of gastric adenocarcinoma. Th...
There are limited reports on methylation analysis of the premalignant lesions of gastric carcinoma t...
Gastric cancer (GC) is one of the most frequent tumors in the world. Stomach adenocarcinoma is a het...
International audienceEpigenetic events have emerged as key mechanisms in the regulation of critical...
Background. The morbidity and mortality rates for gastric cancer (GC) rank second among all cancers,...
Gastric cancer is one of the most common malignancies. DNA methylation is implicated in DNA mismatch...
Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes ...
Transcriptional silencing by CpG island hypermethylation is a potential mechanism for the inactivati...
[[abstract]]BACKGROUND. Loss of E-cadherin expression is found frequently in many types of human mal...
Purpose: Aberrant promoter methylation, an alternative mechanism for gene silencing, is frequently d...
BACKGROUND. Transcriptional silencing by CpG-island hypermethylation now is believed to be an import...
Gastric cancer is the forth most frequent malignancy and the second most common cause of cancer deat...
AIM: To evaluate the methylation status of CDH1, FHIT, MTAP and PLAGL1 promoters and the association...
Promoter hypermethylation is an alternative mechanism of gene silencing in human cancers including g...
DNA methylation has an important impact on normal cell physiology, thus any defects in this mechanis...
Background and Objective. Many factors are involved in the development of gastric adenocarcinoma. Th...
There are limited reports on methylation analysis of the premalignant lesions of gastric carcinoma t...
Gastric cancer (GC) is one of the most frequent tumors in the world. Stomach adenocarcinoma is a het...
International audienceEpigenetic events have emerged as key mechanisms in the regulation of critical...
Background. The morbidity and mortality rates for gastric cancer (GC) rank second among all cancers,...
Gastric cancer is one of the most common malignancies. DNA methylation is implicated in DNA mismatch...
Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes ...
Transcriptional silencing by CpG island hypermethylation is a potential mechanism for the inactivati...
[[abstract]]BACKGROUND. Loss of E-cadherin expression is found frequently in many types of human mal...
Purpose: Aberrant promoter methylation, an alternative mechanism for gene silencing, is frequently d...
BACKGROUND. Transcriptional silencing by CpG-island hypermethylation now is believed to be an import...
Gastric cancer is the forth most frequent malignancy and the second most common cause of cancer deat...
AIM: To evaluate the methylation status of CDH1, FHIT, MTAP and PLAGL1 promoters and the association...
Promoter hypermethylation is an alternative mechanism of gene silencing in human cancers including g...
DNA methylation has an important impact on normal cell physiology, thus any defects in this mechanis...
Background and Objective. Many factors are involved in the development of gastric adenocarcinoma. Th...