Abstract. The disks of spiral galaxies commonly show a lopsided mass distribution, with a typical fractional amplitude of 10 % for the Fourier component m = 1. This is seen in both stars and gas, and the amplitude is higher by a factor of two for galaxies in a group. The study of lopsidedness is a new topic, in contrast to the extensively studied bars and two-armed spirals (m = 2). Here, first a brief overview of the observations of disk lopsidedness is given, followed by a summary of the various mechanisms that have been proposed to explain its physical origin. These include tidal interactions, gas accretion, and a global instability. The pattern speed of lopsidedness in a real galaxy has not been measured so far, the various issues involv...