Add to ORKGElectrophile (Br2) induced cyclization of optically pure N-allyl-β-aminoalcohols 1a, 1b, 1c and 2a, 2b gave chiral morpholines (2R, 5S)-3a, 3b, 3c and (2S, 5R)-4a, 4b respectively. Quenching of the reaction with Na2CO3 after 5 min afforded 60 % conversion with 100 % de, whilst a 2:1 mixture of two diastereomers was obtained upon complete conversion. However, electron donating substituent (OMe) on the para position of the C-2 aryl moiety (substrates 1b and 2b) accelerates the reaction to give 80 % conversion and 50 % isolated yield of single diastereomer after 5 min and 8:1 mixture of diastereomers on complete conversion after 10 min
The synthesis of modified morpholino monomers was performed in a few steps through the condensation ...
Homochiral 2-methylpyrrole derivatives are synthesized in high yields starting from chiral amino alc...
The synthesis of enantiopure 2,6-disubstituted morpholines was realized through sequential ring open...
Chiral 1,2-amino alcohols are privileged scaffolds with important applications as drug candidates an...
Recent advances towards the synthesis of enantiomerically pure substituted morpholines are reported
A novel, straightforward and high yielding synthesis of enantiomerically pure 2,6-disubstituted morp...
Enantiopure 2,6-disubstituted morpholines have been synthesized through the ring opening of chiral, ...
A novel, straightforward and high yielding synthesis of enantiomerically pure 2,6-disubstituted morp...
Two diastereoselective and straightforward protocols for the high-yielding synthesis of 2,3-trans- a...
An efficient and expedient synthetic method was developed for the preparation of chiral poly-substit...
The synthesis of modified morpholino monomers was performed in a few steps through the condensation ...
Homochiral 2-methylpyrrole derivatives are synthesized in high yields starting from chiral amino alc...
The synthesis of enantiopure 2,6-disubstituted morpholines was realized through sequential ring open...
Chiral 1,2-amino alcohols are privileged scaffolds with important applications as drug candidates an...
Recent advances towards the synthesis of enantiomerically pure substituted morpholines are reported
A novel, straightforward and high yielding synthesis of enantiomerically pure 2,6-disubstituted morp...
Enantiopure 2,6-disubstituted morpholines have been synthesized through the ring opening of chiral, ...
A novel, straightforward and high yielding synthesis of enantiomerically pure 2,6-disubstituted morp...
Two diastereoselective and straightforward protocols for the high-yielding synthesis of 2,3-trans- a...
An efficient and expedient synthetic method was developed for the preparation of chiral poly-substit...
The synthesis of modified morpholino monomers was performed in a few steps through the condensation ...
Homochiral 2-methylpyrrole derivatives are synthesized in high yields starting from chiral amino alc...
The synthesis of enantiopure 2,6-disubstituted morpholines was realized through sequential ring open...