Selectivity and equilibrium of chemical reactions can be significantly influenced by the distillation of one or more products from the reaction mixture. Simultaneous reaction and separation of the desired product is very important in the case of consecutive reactions. Simulation of the reactor for propylene oxide (POX) synthesis from propylenechlorohydrine (PCH) and calcium hydroxide is presented in the paper. The main reaction is very fast, followed by hydrolysis of POX in a basic solution into propylene glycol (PGLY). To eliminate the PGLY production, POX is stripped by steam from the reaction mixture. Using the developed model, the optimal design and working performance of the reactor are presented. The role of chemical reaction kinetics...