Add to ORKGApolipoprotein B is the main apolipoprotein of chylomicrons and low density lipoproteins (LDL). It occurs in the plasma in 2 main forms, apoB48 and apoB100. The first is synthesized exclusively by the gut, the second by the liver. ApoB48 is present in chylomicrons and chylomicron remnants and plays an essential role in the intestinal absorption of dietary fats. ApoB100 is a component of VLDL, intermediate density lipoprotein (IDL) and low density lipoproteins (LDL). ApoB100 contributes to hepatic and peripheral tissue uptake of LDL by receptor recognition. Molecular Genetics The Apolipoprotein B gene has been mapped on the short arm of chromosome 2, with an approximate length of 43 kilobases and 29 exons. The LDL-binding domain of the molec...
Apolipoprotein B (apoB, protein; APOB, gene) is the main protein component of low-density lipoprotei...
Background Renewed interest in triglyceride-rich lipoproteins as causative agents in cardiovascular ...
We report the identification and partial characterization of polymorphisms among inbred strains of m...
Background: Plasma lipoproteins are important deter-minants of atherosclerosis. Apolipoprotein (apo)...
Lipoproteins are water-soluble particles of lipids and proteins, which deliver water-insoluble lipid...
This thesis describes the search for genetic variants of the human apolipoprotein B (apoB) gene that...
The role of the apolipoprotein B (apoB) gene in the pathogenesis of two familial hypocholesterolaemi...
Objective—To examine the effects of apoB100 structure, specifically a mutation in the LDLr binding r...
T he two isoforms of apolipoprotein (apo) B, apo B-48 and apo B-100, are important proteins in human...
Familial hypobetalipoproteinaemia is a rare autosomal dominant disorder in which levels of apo-B-con...
Increased levels of cholesterol and triglycerides in the blood are important risk factors for the de...
To examine the effects of apoB100 structure, specifically a mutation in the LDLr binding region, on ...
In a group of 110 subjects with severe coronary artery disease, two were heterozygous for the apolip...
Primary hypobetalipoproteinemias include three monogenic disorders: the relatively frequent codomina...
The class of genetic disorder of LDL―receptor is well established. However, most hypercholesterolemi...
Apolipoprotein B (apoB, protein; APOB, gene) is the main protein component of low-density lipoprotei...
Background Renewed interest in triglyceride-rich lipoproteins as causative agents in cardiovascular ...
We report the identification and partial characterization of polymorphisms among inbred strains of m...
Background: Plasma lipoproteins are important deter-minants of atherosclerosis. Apolipoprotein (apo)...
Lipoproteins are water-soluble particles of lipids and proteins, which deliver water-insoluble lipid...
This thesis describes the search for genetic variants of the human apolipoprotein B (apoB) gene that...
The role of the apolipoprotein B (apoB) gene in the pathogenesis of two familial hypocholesterolaemi...
Objective—To examine the effects of apoB100 structure, specifically a mutation in the LDLr binding r...
T he two isoforms of apolipoprotein (apo) B, apo B-48 and apo B-100, are important proteins in human...
Familial hypobetalipoproteinaemia is a rare autosomal dominant disorder in which levels of apo-B-con...
Increased levels of cholesterol and triglycerides in the blood are important risk factors for the de...
To examine the effects of apoB100 structure, specifically a mutation in the LDLr binding region, on ...
In a group of 110 subjects with severe coronary artery disease, two were heterozygous for the apolip...
Primary hypobetalipoproteinemias include three monogenic disorders: the relatively frequent codomina...
The class of genetic disorder of LDL―receptor is well established. However, most hypercholesterolemi...
Apolipoprotein B (apoB, protein; APOB, gene) is the main protein component of low-density lipoprotei...
Background Renewed interest in triglyceride-rich lipoproteins as causative agents in cardiovascular ...
We report the identification and partial characterization of polymorphisms among inbred strains of m...