Product Notices

noncovalently associates with GPIb (CD42b and c) and GPIX (CD42a) to form a receptor for von Willebrand factor on megakaryocytes and resting platelets. The binding sites for von Willebrand factor and thrombin have been localized to the GPIbachain (CD42b) of the GPIb-V-IX complex. GPV is cleaved by thrombin to release a 69-kDa soluble fragment, which contains the epitope recognized by mAb 1C2. The 1C2 antibody does not cross-react with human platelets nor with other hematopoietic cells of the mouse and rat. Anti-mouse CD41 mAb MWReg30 (Cat. No. 553848, for the FITC conjugate) may be used with mAb 1C2 to monitor mouse megakaryocyte maturation. Preparation and Storage The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. Store undiluted at 4°C. Application Notes Applicatio