Description

The Oligo GEArray ® Human Toxicology and Drug Resistance Microarray profiles the expression of 263 genes related to the metabolic processes of cell stress, cell toxicity, drug resistance, and drug metabolism. Genes critical in drug metabolism and resistance such as those encoding enzymes important for drug transport and phase I metabolism (specifically P450-mediated oxidation) are included. Various covalent modification enzymes important for phase II metabolism are also represented. This array includes genes whose expression level is indicative of stress and toxicity as well as those genes representative of pathways activated by prolonged stress. Among these are genes directly up-regulated by oxidative or metabolic stress and genes involved in cell death by apoptosis or necrosis, growth arrest & senescence, and proliferation & carcinogenesis. Genes involved in cellular stress response are also represented, including those encoding DNA repair enzymes, cell cycle regulators, growth factor and hormone receptors, transcription factors, and molecular chaperones. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples