ORIGINAL ARTICLE TOXICITY AND SURVIVAL OUTCOMES OF HYPERFRACTIONATED SPLIT-COURSE REIRRADIATION AND DAILY CONCURRENT CHEMOTHERAPY IN LOCOREGIONALLY RECURRENT, PREVIOUSLY IRRADIATED HEAD AND NECK CANCERS

Abstract: Background. Reirradiation of locoregionally recurrent, previously irradiated head/neck cancer may be con-sidered in situations of unresectability, medical inoperability, or adverse pathologic features found at salvage resection. Methods. Retrospective cohort analysis of toxicity and sur-vival outcomes in locoregionally recurrent, previously irradiated patients with head/neck cancer treated with hyperfractionated split-course radiotherapy and concurrent chemotherapy