Article ajp.psychiatryonline.org This article is featured in this month’s AJP Audio and is discussed in an editorial by Dr. Freedman on p. 385. Reduced Sleep Spindle Activity in Schizophrenia Patients

represents a powerful new tool to reveal potential abnormalities in rhythm-gener-ating mechanisms while avoiding con-founding factors associated with waking activities. As a first step in this direction, the authors employed high-density EEG to explore whether sleep rhythms differ be-tween schizophrenia subjects, healthy in-dividuals, and a psychiatric control group with a history of depression. Method: Healthy comparison subjects (N=17), medicated schizophrenia patients (N=18), and subjects with a history of de-pression (N=15) were recruited. Subjects were recorded during the first sleep epi