BACKGROUND

Helicobacter pylori (Hp) infects more than half the world adult population and is one of the rare Background Helicobacter pylori (Hp) is a gram negative, spiral shaped bacterium which colonizes the gastric mucosa and induces gastroduodenal complications varying from mild gastritis with no clinical complications to peptic ulcer diseases and even gastric malignancies. The rate of Hp infection is 30-50 % in developed countries whereas it has been rated up to 80 % of the adult population in developing countries like Iran. Hp infection can be detected by various diagnostic methods. Culturing biopsy specimens and Rapid Urease Test (RUT) are the most common and reliable tests which can manifest Hp infection through proper sampling but these methods are invasive ones due to the need for endoscopy procedure in isolation of biopsy specimen. Application of serological assays are being increasingly used for epidemiological studies and detecting systemic immune responses toward past Hp infection. ELISA assays are the most popular techniques particularly in cases with no previous treatment. Materials and Method