Primary Care Respiratory Journal (2008); 17(X): XXX-XXX ORIGINAL RESEARCH Assessing asthma control in routine clinical practice: use of the Royal College of Physicians ‘3 Questions’

Aims: To evaluate the Royal College of Physicians (RCP) ‘3 questions ’ in the assessment of asthma control. Methods: This was a prospective observational study. Subjects (20 adults and 15 children) were assessed 2-weekly over 12 weeks, with data collection on RCP scores (yes/no for each question, 0-3), lung function, asthma control questionnaire (ACQ), asthma quality of life questionnaires (AQLQ), bronchodilator use, and exhaled nitric oxide level. Results: Between-subject analysis showed that the RCP score correlated strongly with the ACQ (correlation coefficient 0.79, p<0.001), AQLQ (-0.71, p=0.001) and bronchodilator use (0.52, p=0.02) in adults, although in children the correlations were weaker and non-significant. Within-subject analysis showed strong correlations between changes in the RCP score and ACQ score in adults (0.67, p<0.001) and children (0.61, p<0.001), between quality of life scores in adults (-0.67, p<0.001) and children (-0.69, p<0.001), and changes in bronchodilator use in adults (0.49, p<0.001) and children (0.48, p<0.001). Weaker or absent correlations existed with lung function and no correlations with exhaled nitric oxide levels. An RCP score of 1 or more identified 89 % of occasions when the ACQ was>1. Conclusions: The RCP 3 questions reliably quantify current asthma control in this dataset, with a negative response to all 3 question