THE EFFICACY OF FENBENDAZOLE * IN THE TREATMENT OF. NATURAL INFECTIONS OF FASCIOLA GIGANTICA AND FASCIOLA HEPATICA IN SHEEP

Summary: The ejficacy Q! fer,bendazole agahıst natural infectioııs of F.gigantica and F.h.cpatica was waluated.. Dose levels of S mg.jkg. b.w. and 7.5 mg.jkg. b.w. removed 23 % and 92 % of F.gigantica burdens. respectively. 28 % of the F.hepatica burden was removed at the highp.rdose leul. Özet: Bu araştırmada F.gıgantica ve F.hepatica ile doğal " enfekte ko-yunlarda fenbendazole'un etkisi denenmiştir. S mg.jkg. ve 7.5 nıg.jkg. hesabedi-lerek verilen bu ilacın koyunlardaki F.gigantica enfeksiyonlarına etkisi sıra-sıyle % 23 ve % '92 olmuştur. Son dozda kullanılan fenbendazole'un ise F. hepatica'yı % 28 yöresinde etkidiği saptanmıştır. Fascioliasis caused by F.gigantica and F.hepatica produces signijicant economic loss in Turkey. Infections tend to be seasonal and affect all ruminant species. With inereasing irrigation being practiced) the disease appears to be spreading. Available information indicates F.gigantica to be more important economiealfy than F.hepatica (S). In the course of an outhrcak of the fomıer infection in 1946,85 % ofa mixedflock ofsheep andgoatsdied (6).. Bajagin (g)found S mg.jkg.fenbendazole to be highly eJfective in Kara-kul sheep infected witlı F.gigantica. Antonov (2) confirmed these fiııdings in sheep naturally infected with Fasciola spp.) 7.5 mg.jkg. fenbendaÇ.ole elimi-natingflukes from the liver andfaecal egg excretian wiıhin 6-10 days of treat-ment