Benzodiazepine potentiation of g-aminobutyric acid (GABA) neu-rotransmission is associated with the presence of a gamma-2 subunit in the GABAA receptor. A method was developed to modify the gamma-2 subunit expression in adult rat brain. Unilat-eral intracerebroventricular (i.c.v.) infusion of a 17-base phospho-rothioate-modified antisense oligodeoxynucleotide (ASO) was performed every 12 hr for 3 days. Controls were treated with a sense oligodeoxynucleotide. Parasagittal brain sections were used for quantitative autoradiographic analysis of radioligand binding. ASO treatment caused a 15 % to 25 % decrease of spe-cific [3H]flunitrazepam binding in most brain areas, with statisti-cally significant decreases in frontal cortex, cerebellar molec...
The present study was designed to evaluate the possible interaction of gamma-hydroxybutyrate (GHB) w...
The present study was designed to evaluate the possible interaction of gamma-hydroxybutyrate (GHB) w...
Cloned cDNAs encoding a member of the &gamma:-aminobutyric acid type A receptor &gamma:-subunit clas...
Chronic benzodiazepine treatment can produce tolerance and changes in g-aminobutyric acid (GABA)A re...
Chronic benzodiazepine treatment can produce tolerance and changes in g-aminobutyric acid (GABA)A re...
GABA, a major inhibitory transmitter, is used by many projection neurons of the striatum. To investi...
Cultured neurons from embryonic rat brain display central type benzodiazepine receptors characterize...
Neurotransmission effected by GABA (gamma-aminobutyric acid) is predominantly mediated by a gated ch...
A cDNA encoding a protein with 70% amino acid identity to the previously characterized gamma-aminobu...
The astrocytic enzyme glutamine synthetase (GS) is a key regulator of glutamate and γ-aminobutyric a...
We compared gamma-aminobutyric acid (GABA)-activated currents and their modulation by benzodiazepine...
The effect of gamma-aminobutyric acid (GABA) on the binding of PK 8165, a quinoline derivative, and ...
The effect of gamma-aminobutyric acid (GABA) on the binding of PK 8165, a quinoline derivative, and ...
Gamma-Amino butyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central ner...
Benzodiazepines potentiate gamma-aminobutyric acid type A receptor (GABA(A)R) activity and are widel...
The present study was designed to evaluate the possible interaction of gamma-hydroxybutyrate (GHB) w...
The present study was designed to evaluate the possible interaction of gamma-hydroxybutyrate (GHB) w...
Cloned cDNAs encoding a member of the &gamma:-aminobutyric acid type A receptor &gamma:-subunit clas...
Chronic benzodiazepine treatment can produce tolerance and changes in g-aminobutyric acid (GABA)A re...
Chronic benzodiazepine treatment can produce tolerance and changes in g-aminobutyric acid (GABA)A re...
GABA, a major inhibitory transmitter, is used by many projection neurons of the striatum. To investi...
Cultured neurons from embryonic rat brain display central type benzodiazepine receptors characterize...
Neurotransmission effected by GABA (gamma-aminobutyric acid) is predominantly mediated by a gated ch...
A cDNA encoding a protein with 70% amino acid identity to the previously characterized gamma-aminobu...
The astrocytic enzyme glutamine synthetase (GS) is a key regulator of glutamate and γ-aminobutyric a...
We compared gamma-aminobutyric acid (GABA)-activated currents and their modulation by benzodiazepine...
The effect of gamma-aminobutyric acid (GABA) on the binding of PK 8165, a quinoline derivative, and ...
The effect of gamma-aminobutyric acid (GABA) on the binding of PK 8165, a quinoline derivative, and ...
Gamma-Amino butyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central ner...
Benzodiazepines potentiate gamma-aminobutyric acid type A receptor (GABA(A)R) activity and are widel...
The present study was designed to evaluate the possible interaction of gamma-hydroxybutyrate (GHB) w...
The present study was designed to evaluate the possible interaction of gamma-hydroxybutyrate (GHB) w...
Cloned cDNAs encoding a member of the &gamma:-aminobutyric acid type A receptor &gamma:-subunit clas...