Expression of p53, c-erbB-2 and Ki67 in intestinal metaplasia and gastric carcinoma

AIM: To compare two types of classification of intestinal metaplasia (IM) of the stomach and to explore their relationship to gastric carcinoma. METHODS: Forty-seven cases of gastric IM were classified into type , type or type according to mucin histochemical staining and compared with a novel classification in which the specimens were classified into simple IM (SIM) or atypical IM according to polymorphism in terms of atypical changes of the metaplastic epithelium. Forty-seven IM and thirty-seven gastric carcinoma samples were stained for p53, c-erbB-2 and Ki67 proteins by Envision immunohistochemical technique. RESULTS: There were no significant differences in th