RELAPSE OF WEGENER’S GRANULOMATOSIS IN THE FIRST TRIMESTER OF

The association of Wegener’s granulomatosis and pregnancy is rare and poses unique therapeutic challenges, particularly when active disease presents in early pregnancy. We describe a 22-yr-old woman who recovered successfully from her initial episode of Wegener’s granulomatosis with a standard course of treatment with prednisolone and cyclophosphamide. Two and a half years later, she presented with relapse during the first trimester of pregnancy (primigravida). Since the clinical features suggested mild disease, she was started on prednisolone at a dose of 1 mg/kg/day, to which she seemed to respond very well for 3 months. Unfortunately, she had a spontaneous abortion at 5 months of gestation while on 25 mg/day of prednisolone. At this time, her disease flared further, with clinically manifest lung disease which was not part of her initial presentation. She was treated with another course of oral cyclophosphamide and prednisolone, and a remission was achieved in 4 months. There are no agreed guidelines on the treatment of Wegener’s granulomatosis during pregnancy. In this report, the therapeutic issues are discussed against the background of the available literature. Key words: Wegener’s granulomatosis, Relapse, Treatment, Pregnancy. she was started on standard treatment consisting of pred-The association of Wegener’s granulomatosis (WG) nisolone 1 mg/kg/day and cyclophosphamide 2 mg/kg/day,with pregnancy is rare because the peak incidence of orally. She was given an explanation of the short- and long-the disease occurs in the fourth and fifth decades [1]. term risks of cyclophosphamide therapy, and informed con-To date, only 20 instances of such an association hav