Add to ORKGWe determined whether chronic endothelin-1 (ET-1) treatment could lead to in vivo insulin resistance. Like insulin, ET-1 acutely stimulated glucose transport in isolated soleus muscle strips of WKY rats. ET-1 pre-treatment (1 h) decreased insulin-stimulated glucose transport in muscle strips (23%). Both ET-1–mediated effects were generated through ETA receptors, because a specific ETA receptor antagonist (BQ610) blocked these effects of ET-1. Osmotic minipumps were used to treat normal rats with ET-1 for 5 days. Subsequent hyperinsulinemic-euglycemic clamps showed that ET-1 treatment led to an 30 % decrease in insulin-stimu-lated glucose disposal rates in male and female rats. In addition, ex vivo study of soleus muscle strips showed decrea...
The present thesis examined the role of endothelin-1 (ET-1), a potent 21-aminoacid vasoconstrictor-...
Insulin promotes vasodilatory, vasoconstrictor and atherogenic influences on vascular smooth muscle....
Glucose uptake occurs in skeletal muscle under basal conditions, and increases in response to stimul...
\(Aims/hypothesis\) Plasma levels of endothelin-1 are frequently elevated in patients with hypertens...
Background and Purpose: Endothelin-1 (ET-1) reduces insulin-stimulated glucose uptake in skeletal mu...
Insulin resistance plays a major role in the pathogenesis of type 2 diabetes and is an important ri...
flammatory peptide that may interfere with glucose uptake. Our objective was to investigate whether ...
This study investigated the role of endothelin-1 for hyperglycemia, vascular, and pancreatic injury ...
Insulin replacement is the only effective therapy to manage hyperglycemia in type 1 diabetes mellitu...
In the aorta of prediabetic non-obese diabetic mice, a model of human type 1 diabetes, we investigat...
High salt intake (HS) is associated with obesity and insulin resistance. ET-1, a peptide released in...
[[abstract]]Resistin is an adipocyte-derived hormone whose role in the development of insulin resist...
Insulin resistance is a potent and highly prevalentrisk factor for diabetes and cardiovascular disea...
Endothelium-dependent vasodilation is impaired in clin-ical states of insulin resistance such as obe...
<p>Obstructive sleep apnea (OSA) is associated with insulin resistance (IR) and glucose intolerance....
The present thesis examined the role of endothelin-1 (ET-1), a potent 21-aminoacid vasoconstrictor-...
Insulin promotes vasodilatory, vasoconstrictor and atherogenic influences on vascular smooth muscle....
Glucose uptake occurs in skeletal muscle under basal conditions, and increases in response to stimul...
\(Aims/hypothesis\) Plasma levels of endothelin-1 are frequently elevated in patients with hypertens...
Background and Purpose: Endothelin-1 (ET-1) reduces insulin-stimulated glucose uptake in skeletal mu...
Insulin resistance plays a major role in the pathogenesis of type 2 diabetes and is an important ri...
flammatory peptide that may interfere with glucose uptake. Our objective was to investigate whether ...
This study investigated the role of endothelin-1 for hyperglycemia, vascular, and pancreatic injury ...
Insulin replacement is the only effective therapy to manage hyperglycemia in type 1 diabetes mellitu...
In the aorta of prediabetic non-obese diabetic mice, a model of human type 1 diabetes, we investigat...
High salt intake (HS) is associated with obesity and insulin resistance. ET-1, a peptide released in...
[[abstract]]Resistin is an adipocyte-derived hormone whose role in the development of insulin resist...
Insulin resistance is a potent and highly prevalentrisk factor for diabetes and cardiovascular disea...
Endothelium-dependent vasodilation is impaired in clin-ical states of insulin resistance such as obe...
<p>Obstructive sleep apnea (OSA) is associated with insulin resistance (IR) and glucose intolerance....
The present thesis examined the role of endothelin-1 (ET-1), a potent 21-aminoacid vasoconstrictor-...
Insulin promotes vasodilatory, vasoconstrictor and atherogenic influences on vascular smooth muscle....
Glucose uptake occurs in skeletal muscle under basal conditions, and increases in response to stimul...