EDUCATIONAL OBJECTIVE: Readers will assess the current evidence for using coenzyme Q10 supplements

A therapy for hypertension and statin-induced myalgia? Some small clinical trials seem to show that coenzyme Q10 supplements can be used to lower blood pressure and to treat or prevent myalgia caused by hydroxy-methylglutaryl coenzyme A reductase inhibitors (statins). However, larger trials are needed to determine if they are truly effective for these purposes. The authors examine the evidence and also discuss issues such as bioavailabil-ity, elimination, safety, and cost. ■ KEY POINTS In some clinical trials, coenzyme Q10 supplements sig-nificantly lowered diastolic and systolic blood pressure. Statins may lower coenzyme Q10 serum levels, and som