Molecular Identification of Hyaluronic Acid Genes of Streptococcus pyogenes

The genes responsible for hyaluronic acid (HA) production (has A,has B and has C genes) of eight local S. pyogenes isolates were identified using polymerase chain reaction(PCR). It was found that all isolates possessed has A and has B genes whereas has C gene was found in three isolates of S. pyogenes . This study supports the opinion that has A and has B genes are required for direct HA biosynthesis, while has C gene is not required for HA production