We investigate isospin-symmetry breaking effects in the sd-shell region with large-scale shell-model calculations, aiming to understand the recent anomalies observed in superallowed Fermi β-decay. We begin with calculations of Coulomb displacement energies (CDE's) and triplet displacement energies (TDE's) by adding the T=1,J=0 isospin nonconserving (INC) interaction into the usual isospin-invariant Hamiltonian. It is found that CDE's and TDE's can be systematically described with high accuracy. A total number of 122 one- and two-proton separation energies are predicted accordingly, and locations of the proton drip-line and candidates for proton-emitters are thereby suggested. However, attempt to explain the anomalies in the superallowed Fer...