Advances in Translational Medicine of Basic Breast Cancer

Breast cancer is one of the most common malignancies in women, and about 1 200 000 women are suffering from breast cancer all over the world annually, thus becoming the top one killer of female health. In recent years, with the rapid development of human genomics, proteomics and bioinformatics, various high-tech detection methods are emerging constantly, and a basic and clinical study results on breast cancer have emerged endlessly. Only if basic research can answer or resolve clinical problems can it be valuable, while translational medicine is just the bridge that connects basic research and clinical practice. Translational medicine is a bidirectional, open and circulatory scientific research and management system, aiming to promote the open cross fusion and cooperation of multidisciplinaries by establishing a bidirectional translational pathway between basic research and clinical practice, to break the barrier between basic research and clinical practice in order to guide the scientifc researchers to resolve clinical problems and conduct basic research for the targets, and to effciently promote the biomedicine-oriented basic research results to be transformed into drugs, instruments, methods, mechanisms and specifications that can be practically applied in clinic by circulating methods, so as to better serve for human health. This study mainly reviewed the concept of translational medicine, breast cancer-related molecular markers, and the individual therapeutic protocols and targeted therapies for breast cancer, hoping to provide reference for early diagnosis and treatment of breast cancer