A comparison between Zhishi Xiaopiwan and cisapride in treatment of functional dyspepsia *

Subject headings Dyspepsia/therapy; Zhishi xiaopi; cisapride; gastric emptying AIM To compare the therapeutic effect of the herbal medicine Zhishi Xiaopi with that of Cisapride in the treatment of functional dyspepsia (FD). METHODS Fifty-one FD patients were randomized into Herbal group (n = 27) and Cisapride group (n = 24). Two two groups were given a four-week treatment of Zhishi Xiaopiwan 100ml, tid, a.c. and Cisapride 5mg, tid, a.c. respectively. Patients ’ symptoms were assessed and 39 patients ’ (22 of Herbal group and 17 of Cisapride group) gastric liquid emptying times were measured with ultrasonography before and after the treatment. RESULTS The therapeutic effective rates of Herbal group and Cisapride group were 81.49% and 87.50 % (P>0.05). The half gastric emptying time (GET50) and gastric emptying time (GET) of healthy controls and FD patients were 36.12min±10.22min vs 52.95min±13.49min an