Advance Access publication xx xx xxxx Original Article Renal magnesium wasting and tubular dysfunction in leptospirosis

Background. Tubulo-interstitial nephritis is the main cause of acute renal injury in leptospirosis. The aim of this study was to evaluate renal tubular function and excretion of so-lutes in leptospirosis patients during a recent outbreak of leptospirosis in Nan province, Thailand. Methods. Clinical manifestations were recorded and rou-tine laboratory tests were performed upon admission. Renal tubular functions including tubular reabsorption of phosphate (TRP), fractional excretion of magnesium (FEMg), urinary calcium to creatinine ratio (Uca/cr), urine N-acetyl-β-D glucosaminidase (NAG) and urine β2-microglobulin were serially monitored during 2 weeks after admission. Results. A total of 20 leptospirosis patients were recruited