This paper presents results from an MDO design procedure illustrating the eects of numerous trim, control, and performance requirements for a high speed civil transport. We optimize the design for minimum take o gross weight, including both aerodynamics and structures to nd the wing planform and thickness distribution, fuselage shape, engine placement and thrust, using 29 design variables and 70 constraints to insure realistic results. The constraints include the engine-out and crosswind landing requirements, as well as engine nacelle ground strike, rotation to lift-o attitude, balanced eld length and approach trim constraints. We found that the engine-out condition and the engine nacelle ground strike avoidance were critical conditions. ...