Caffine and Heart Disease What is The depate

Background Epidemiological studies examining the association between coffee consumption and risk of CHD have been equivocal. Coffee contains several biologically active substances that may have either beneficial or harmful effects on the cardiovascular system. Antioxidants or other protective compounds present in coffee may contribute to a lower risk of CHD among moderate drinkers of filtered coffee who are rapid metabolizers of caffeine. The incorporation of genetic modifiers of exposure or biologic effect of these compounds to the study of coffee and CHD could help identify these compounds and provide a better understanding of how they might protect against CHD. The present study comprised two groups; the chronic coffee and /or tea drinkers group (A) and the caffeine-naive group (B). Group (A) included ten (10) patients with essential hypertension; twelve (12) patients with ischaemic heart disease (IHD) and ten (10) healthy adults. Group (B) included ten (10) healthy caffeine- naive individuals as a control group. All the partici-pants in the study were males, their age ranged between 24-60 years. All were given a boostering dose of caffeine (250 mg) and were subjected to treadmill exercise ECG testing and echocardiographic study before and after the boostering dose. Their caffeine and enkephalins serum levels were also determined before and after the tread-mill exercise ECG testing. Conclustion: the results of the study showed that the chronic coffee and or tea drinkers whether they were patients or healthy individuals were tolerant to the cardiovascular effects of caffeine in moderate doses and the enkephalins may have a role in the development of this toleranc