phosphatidylinositol (PI), collectively called phosphoinositides, regulate many important cellular signaling pathways. Lipid signaling disorders are linked to the development of several severe diseases in humans (1). Conse-quently, there is an increasing interest in the identification of proteins that interact with these lipids. The recent discovery of phosphoinositide-binding domains such as pleckstrin homology (PH), Fab1, YOTB, Vac1, and EEA1 (FYVE), phox homology (PX), and epsin N-terminal homology (ENTH) domains (2) has sped up the discover
AbstractLipid signaling by phosphoinositides (PIPns) involves an array of proteins with lipid recogn...
210 pagesPhosphoinositides (PIPs) are essential lipids that localize in the cytoplasmic leaflet of t...
The human genome encodes about 285 proteins that contain at least one annotated pleckstrin homology ...
u interacting pleckstrin homology (PH) domains, which comprehensive mapping of proteomes (de Godoy e...
The discovery that PSD-95/Discs large/ZO-1 (PDZ) domains can function as lipid-binding modules, in p...
Pleckstrin homology (PH) domains are presumed to bind phosphoinositides (PIPs) but only few specific...
1-5Research into phospholipid signaling continues to flourish, as more and more bioactive lipids an...
AbstractPhosphatidylinositol 3-phosphate directs the endosomal localization of regulatory proteins b...
Lipid second messengers generated by phosphoinositide (PI) 3-kinases regulate diverse cellular funct...
Anionic lipids act as signals for the recruitment of proteins containing cationic clusters to biolog...
Many cellular processes involve the recruitment of proteins to specific membranes, which are decorat...
Phosphoinositides (PIPs) play key roles in signaling and disease. Using high-resolution quantitative...
THE pleckstrin homology (PH) domain is a new protein module of around 100 amino acids found in sever...
The human genome encodes about 285 proteins that contain at least one annotated pleckstrin homology ...
SummaryMany cellular processes involve the recruitment of proteins to specific membranes, which are ...
AbstractLipid signaling by phosphoinositides (PIPns) involves an array of proteins with lipid recogn...
210 pagesPhosphoinositides (PIPs) are essential lipids that localize in the cytoplasmic leaflet of t...
The human genome encodes about 285 proteins that contain at least one annotated pleckstrin homology ...
u interacting pleckstrin homology (PH) domains, which comprehensive mapping of proteomes (de Godoy e...
The discovery that PSD-95/Discs large/ZO-1 (PDZ) domains can function as lipid-binding modules, in p...
Pleckstrin homology (PH) domains are presumed to bind phosphoinositides (PIPs) but only few specific...
1-5Research into phospholipid signaling continues to flourish, as more and more bioactive lipids an...
AbstractPhosphatidylinositol 3-phosphate directs the endosomal localization of regulatory proteins b...
Lipid second messengers generated by phosphoinositide (PI) 3-kinases regulate diverse cellular funct...
Anionic lipids act as signals for the recruitment of proteins containing cationic clusters to biolog...
Many cellular processes involve the recruitment of proteins to specific membranes, which are decorat...
Phosphoinositides (PIPs) play key roles in signaling and disease. Using high-resolution quantitative...
THE pleckstrin homology (PH) domain is a new protein module of around 100 amino acids found in sever...
The human genome encodes about 285 proteins that contain at least one annotated pleckstrin homology ...
SummaryMany cellular processes involve the recruitment of proteins to specific membranes, which are ...
AbstractLipid signaling by phosphoinositides (PIPns) involves an array of proteins with lipid recogn...
210 pagesPhosphoinositides (PIPs) are essential lipids that localize in the cytoplasmic leaflet of t...
The human genome encodes about 285 proteins that contain at least one annotated pleckstrin homology ...