Plasminogen Activator Inhibitor 1 4G/5G Polymorphism and Coagulation Factor XIII

Background: A successful outcome of pregnancy de-pends on proper placental formation. In the very begin-ning of this process, trophoblast invasion and fibrin deposition into the wall of the decidual veins play an important part. Two polymorphisms, coagulation factor XIII (FXIII) Val34Leu and plasminogen activator inhib-itor 1 (PAI-1) 4G/5G, interfere with fibrin cross-linking and regulation of fibrinolysis and may therefore con-tribute to early pregnancy loss. Methods: We enrolled 49 unrelated Caucasian women with a history of two consecutive or three to six noncon-secutive early pregnancy losses and 48 unrelated parous healthy controls without a history of pregnancy loss and evaluated them for the following genetic variants: the factor V Leiden and prothrombin G20210A gene muta-tions, the methylenetetrahydrofolate reductase C677