Particle size and shape control in crystallization process

Crystallization from solution is an industrially important unit operation due to its ability to provide high purity separa-tions. The control of the crystal size distribution can be critically important for efficient downstream operations such as filtration and drying, and product effectiveness (e.g., bioavailability, tablet stability). This paper provides an overview on recent developments in the control of industrial crystallization processes. This includes descriptions of recent activ-ities in the modeling, parameter estimation, state estimation, analysis, simulation, optimization, control, and design of crystallization processes