Apert syndrome (AS) is one of at least nine disorders considered members of the fibroblast growth factor receptor (FGFR)-1,-2, and-3–related craniosynostosis syndromes. Nearly 100 % of individuals diagnosed with AS carry one of two neighboring mutations on Fgfr2. The cranial phenotype associated with these two mutations includes coronal suture synostosis, either unilateral (unicoronal synostosis) or bilateral (bicoronal synostosis). Brain dysmorphology associated with AS is thought to be secondary to cranial vault or base alterations, but the variation in brain phenotypes within Apert syndrome is unexplained. Here, we present novel three-dimensional data on brain phenotypes of inbred mice at postnatal day 0 each carrying one of the two Fgfr...
Background: Apert syndrome is considered as one of the most common craniosynostosis syndromes with a...
Cranial sutures are unossified connective tissue structures between the cranial bones, which allow e...
Apert syndrome is a rare genetic disorder characterized by craniosynostosis, midface retrusion, and ...
Apert syndrome (AS) is one of at least nine disorders considered members of the FGFR-1, -2, and -3-r...
Apert Syndrome (AS) is one of several fibroblast growth factor receptor (FGFR) related craniosynosto...
Apert syndrome is a disorder associated with craniosynostosis resulting from one of two mutations in...
<div><p>Apert syndrome (AS), the most severe form craniosynostosis, is characterized by premature fu...
Apert syndrome (AS), the most severe form craniosynostosis, is characterized by premature fusion of ...
The fibroblast growth factor and receptor system (FGF/FGFR) mediates cell communication and pattern ...
The form and function of the craniofacial structure critically depend on genetic information. With r...
Objective: Activating mutations in the fibroblast growth factor receptor-2 (FGFR2) have been shown t...
SUMMARY Apert syndrome is a congenital disorder characterized by severe skull malformations and caus...
WOS: 000425647900009PubMed ID: 29483804Apert syndrome is an autosomal dominant craniosynostosis synd...
Apert syndrome is a rare acrocephalosyndactyly (craniosynostosis) syndrome characterized by craniofa...
Apert syndrome (AS), the most severe form of craniosynostosis, is caused by missense mutations inclu...
Background: Apert syndrome is considered as one of the most common craniosynostosis syndromes with a...
Cranial sutures are unossified connective tissue structures between the cranial bones, which allow e...
Apert syndrome is a rare genetic disorder characterized by craniosynostosis, midface retrusion, and ...
Apert syndrome (AS) is one of at least nine disorders considered members of the FGFR-1, -2, and -3-r...
Apert Syndrome (AS) is one of several fibroblast growth factor receptor (FGFR) related craniosynosto...
Apert syndrome is a disorder associated with craniosynostosis resulting from one of two mutations in...
<div><p>Apert syndrome (AS), the most severe form craniosynostosis, is characterized by premature fu...
Apert syndrome (AS), the most severe form craniosynostosis, is characterized by premature fusion of ...
The fibroblast growth factor and receptor system (FGF/FGFR) mediates cell communication and pattern ...
The form and function of the craniofacial structure critically depend on genetic information. With r...
Objective: Activating mutations in the fibroblast growth factor receptor-2 (FGFR2) have been shown t...
SUMMARY Apert syndrome is a congenital disorder characterized by severe skull malformations and caus...
WOS: 000425647900009PubMed ID: 29483804Apert syndrome is an autosomal dominant craniosynostosis synd...
Apert syndrome is a rare acrocephalosyndactyly (craniosynostosis) syndrome characterized by craniofa...
Apert syndrome (AS), the most severe form of craniosynostosis, is caused by missense mutations inclu...
Background: Apert syndrome is considered as one of the most common craniosynostosis syndromes with a...
Cranial sutures are unossified connective tissue structures between the cranial bones, which allow e...
Apert syndrome is a rare genetic disorder characterized by craniosynostosis, midface retrusion, and ...